Perivascular Adipose Tissue Oxidative Stress on the Pathophysiology of Cardiometabolic Diseases

Author(s)

Victorio, Jamaira A. ^[1] ; Davel, Ana P. ^[1]

Affiliation

^[1] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil

• Document type: Review article
• Source: CURRENT HYPERTENSION REVIEWS; v. 16, n. 3, p. 192-200, 2021.
• Web of Science Citations: 4

Abstract

Most of the systemic blood vessels are surrounded by the perivascular adipose tissue (PVAT). Healthy PVAT is anticontractile and anti-inflammatory, but a dysfunctional PVAT has been suggested to link cardiometabolic risk factors to vascular dysfunction. Vascular oxidative stress is an important pathophysiological event in cardiometabolic complications of obesity, type 2 diabetes, and hypertension. PVAT-derived adipocytes generate reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide that might signal to the vascular wall. Therefore, an abnormal generation of ROS by PVAT emerges as a potential pathophysiological mechanism underlying vascular injury. This review summarizes new findings describing ROS production in the PVAT of several vascular beds, major sources of ROS in this tissue including mitochondria, NADPH oxidase and eNOS uncoupled, and finally, changes in ROS production affecting vascular function in the presence of cardiometabolic risk factors and diseases. (AU)

• FAPESP's process: 18/00543-8 - The role of endothelial and macrophage mineralocorticoid receptor in inflammation response and anti-contractile function of perivascular adipose tissue in obese male and female
• Grantee: Jamaira Aparecida Victorio
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/16505-8 - Perivascular adipose tissue dysfunction and inflammation in obesity: the role of mineralocorticoid receptors
• Grantee: Ana Paula Couto Davel
• Support Opportunities: Regular Research Grants