HLA-DPB1 and HLA-C alleles are associated with leprosy in a Brazilian population

Author(s):Show less -

de Souza-Santana, Fabiana Covolo ^[1] ; Querino, Gislaine Aparecida ^{[2, 1]} ; Camargo, Rodrigo Mendes ^{[2, 1]} ; Brito de Souza, Vania Nieto ^{[2, 1]} ; Ballallai Mangilli, Priscila Bettoni ^[1] ; Mira, Marcelo Tavora ^[3] ; Bezerra, Ohanna Cavalcanti ^[4] ; Kehdy, Fernanda ^[4] ; Laguila Visentainer, Jeane Eliete ^[5] ; Alves, Hugo Vicentin ^[5] ; Jarduli, Luciana Ribeiro ^[5] ; Moraes, Milton Ozorio ^[4] ; Camarinha Marcos, Elaine Valin ^[1] ; Pereira Latini, Ana Carla ^{[2, 1]}

Affiliation

^[1] Lauro de Souza Lima Inst, Rodovia Comandante Joao Ribeiro de Barros Km 225, BR-17034971 Bauru, SP - Brazil

^[2] Sao Paulo State Univ Unesp, Med Sch, BR-18618687 Botucatu, SP - Brazil

^[3] Pontificia Univ Catolica Parana, Sch Med, Grad Program Hlth Sci, BR-80215901 Curitiba, Parana - Brazil

^[4] Oswaldo Cruz Inst Fiocruz, Leprosy Lab, BR-21040360 Rio De Janeiro - Brazil

^[5] Maringa State Univ UEM, Dept Basic Hlth Sci, Lab Immunogenet, BR-87020900 Maringa, Parana - Brazil

• Document type: Journal article
• Source: HUMAN IMMUNOLOGY; v. 82, n. 1, p. 11-18, JAN 2021.
• Web of Science Citations: 0

Abstract

Despite intense efforts, the number of new cases of leprosy has remained significantly high over the past 20 years. Host genetic background is strongly linked to the pathogenesis of this disease, which is caused by Mycobacterium leprae (M. leprae), and there is a consensus that the most significant genetic association with leprosy is attributed to the major histocompatibility complex (MHC). Here, we investigated the association of human leukocyte antigen (HLA) class I and II genes with leprosy in a Brazilian population encompassing 826 individuals from a hyperendemic area of Brazil; HLA typing of class I (-A, -B, -C) and class II (-DRB1, -DQA1, -DQB1, -DPA1, and -DPB1) loci was conducted. Initially, the associations were tested using the chi-square test, with p-values adjusted using the false discovery rate (FDR) method. Next, statistically significant signals of the associations were submitted to logistic regression analyses to adjust for sex and molecular ancestry data. The results showed that HLA-C{*}08,-DPB1{*}04, and-DPB1{*}18 were associated with protective effects, while HLA-C{*}12 and-DPB1{*}105 were associated with susceptibility to leprosy. Thus, our findings reveal new associations between leprosy and the HLA-DPB1 locus and confirm previous associations between the HLA-C locus and leprosy. (c) 2020 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 09/16873-8 - Genetic epidemiology in leprosy: association study of 6p21, 17q22, 20p13 and 10p13 candidate regions
• Grantee: Ana Carla Pereira Latini
• Support type: Regular Research Grants