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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exercise Training as Therapeutic Approach in Cancer Cachexia: A Review of Potential Anti-inflammatory Effect on Muscle Wasting

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Author(s):
Leal, Luana G. [1, 2] ; Lopes, Magno A. [3] ; Peres, Sidney B. [4] ; Batista, Jr., Miguel L. [1, 2]
Total Authors: 4
Affiliation:
[1] Univ Mogi Das Cruzes, Integrated Grp Biotechnol, Lab Adipose Tissue Biol, Mogi Das Cruzes, SP - Brazil
[2] Univ Mogi Das Cruzes, Technol Res Grp, Mogi Das Cruzes, SP - Brazil
[3] Czech Acad Sci, Inst Physiol, Lab Metab Bioact Lipids, Prague - Czech Republic
[4] Univ Estadual Maringa, Dept Physiol Sci, Maringa, Parana - Brazil
Total Affiliations: 4
Document type: Review article
Source: FRONTIERS IN PHYSIOLOGY; v. 11, FEB 4 2021.
Web of Science Citations: 0
Abstract

Cachexia is a multifactorial inflammatory syndrome with high prevalence in cancer patients. It is characterized by a metabolic chaos culminating in drastic reduction in body weight, mainly due to skeletal muscle and fat depletion. Currently, there is not a standard intervention for cachexia, but it is believed that a dynamic approach should be applied early in the course of the disease to maintain or slow the loss of physical function. The present review sought to explain the different clinical and experimental applications of different models of exercise and their contribution to a better prognosis of the disease. Here the advances in knowledge about the application of physical training in experimental models are elucidated, tests that contribute substantially to elucidate the cellular and biochemical mechanisms of exercise in different ways, as well as clinical trials that present not only the impacts of exercise in front cachexia but also the challenges of its application in clinical practice. (AU)

FAPESP's process: 18/20905-1 - TLR4 as crossroad of inflammation and energy metabolism: Role of adipose tissue in cancer cachexia
Grantee:Miguel Luiz Batista Junior
Support Opportunities: Scholarships abroad - Research
FAPESP's process: 15/19259-0 - Effects of adipose tissue remodeling during cachexia in gastrointestinal cancer patients: potential role of TLR4 receptor during cachexia-induced browning of WAT
Grantee:Miguel Luiz Batista Junior
Support Opportunities: Regular Research Grants