Immunohistochemical Expression of Vascular Endothelial Growth Factor as a Prognostic Marker for Canine Mast Cell Tumors

Author(s)

Melo, Samanta Rios ^[1] ; Januario, Eric Vieira ^[1] ; Zanuto, Erika ^[1] ; Miranda, Bruna de Castro ^[1] ; Macedo, Thais Rodrigues ^[1] ; Cogliati, Bruno ^[1] ; Matera, Julia Maria ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Surg, Sao Paulo - Brazil

• Document type: Journal article
• Source: TOPICS IN COMPANION ANIMAL MEDICINE; v. 42, MAR 2021.
• Web of Science Citations: 1

Abstract

Strong to moderate vascular endothelial growth factor (VEGF) expression may be a negative prognostic factor in canine mast cell tumors (MCTs). This study set out to determine the prognostic value of combined analysis of VEGF-A immunoreactivity, clinical presentation, patient staging, and tumor histologic grade in canine MCTs. In this study, intense VEGF staining was significantly associated with decreased survival (P = .025). Immunohistochemical expression of VEGF is not routinely employed as a prognostic factor in canine MCT workup. However, results of this study support the inclusion of this marker in the MCT prognostic panel. Investigation of VEGF expression may assist in the development of anti-VEGF drugs. (C)y 2020 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 13/21044-6 - Vascularization analysis of pedicled skin flaps in dogs through thermographic camera
• Grantee: Samanta Rios Melo
• Support Opportunities: Scholarships in Brazil - Doctorate