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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prevalence of Focal Inner, Middle, and Combined Retinal Thinning in Diabetic Patients and Its Relationship With Systemic and Ocular Parameters

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Preti, Rony Carlos [1] ; Iovino, Claudio [2] ; Abalem, Maria Fernanda [1, 3] ; Garcia, Rafael [1] ; Veloso dos Santos, Helen Nazareth [1] ; Sakuno, Gustavo [1] ; Au, Adrian [4] ; Cunha, Leonardo Provetti [1] ; Zacharias, Leandro Cabral [1, 5] ; Ribeiro Monteiro, Mario Luiz [1] ; Sadda, Srinivas Reddy [6, 4] ; Sarraf, David [4, 7]
Total Authors: 12
[1] Univ Sao Paulo, Div Ophthalmol, Sch Med, Sao Paulo - Brazil
[2] Univ Campania Luigi Vanvitelli, Multidisciplinary Dept Med Surg & Dent Sci, Eye Clin, Naples - Italy
[3] Univ Michigan, Kellogg Eye Ctr, Ann Arbor, MI 48109 - USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Stein Eye Inst, Los Angeles, CA 90095 - USA
[5] Univ Fed Juiz de Fora, Dept Ophthalmol, Sch Med, Juiz De Fora - Brazil
[6] Doheny Eye Inst, 1355 San Pablo St, Los Angeles, CA 90033 - USA
[7] Greater Los Angeles Vet Affairs Healthcare Ctr, Los Angeles, CA - USA
Total Affiliations: 7
Document type: Journal article
Web of Science Citations: 0

Purpose: To determine the prevalence of focal inner, middle, and combined inner/middle retinal thinning (FIRT, FMRT, and FCRT, respectively) in different stages of diabetic retinopathy (DR) without diabetic macular edema and to assess the relationship between such findings with ocular and systemic parameters. Methods: This was a cross-sectional, comparative study comprising healthy participants and diabetic patients with different stages of DR. Forty-nine horizontal macular B-scans from the selected eye were obtained using spectral-domain optical coherence tomography (SD-OCT) and analyzed for the presence of FIRT, FMRT, or FCRT and any relationship with systemic and ocular parameters. Focal retinal thinning (FRT) was subjectively defined as any evidence of inner and/or middle retinal thinning. Results: A total of 190 participants (52 healthy participants and 138 diabetic patients) were included. A higher prevalence of FRT was observed in eyes with advanced DR versus healthy eyes and versus diabetic eyes with no DR or mild DR. FIRT and FCRT were significantly greater in eyes with proliferative DR treated with pan-retinal photocoagulation, and FMRT was significantly more common in eyes with severe nonproliferative DR. FRT was significantly more common in patients with coronary artery disease and was positively correlated with diabetes duration, serum creatinine, and glycosylated hemoglobin and negatively correlated with age, estimated glomerular filtration rate, and visual acuity. Conclusions: FRT occurs in all stages of DR and is increasingly prevalent with increasing severity of DR. Translational Relevance: OCT identification of FRT may provide a surrogate biomarker of retinal and systemic disease in diabetic patients. (AU)

FAPESP's process: 14/25354-2 - Structural evaluation of the retina and choroid by optical coherence tomography in diabetic patients with or without renal involvement
Grantee:Rony Carlos Preti
Support Opportunities: Regular Research Grants