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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An update on brown adipose tissue biology: a discussion of recent findings

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Author(s):
Gaspar, Rafael C. [1, 2] ; Pauli, Jose R. [3, 1] ; Shulman, I, Gerald ; Munoz, Vitor R. [1]
Total Authors: 4
Affiliation:
[1] Univ Estadual Campinas, Sch Appl Sci, Dept Hlth Sci, Lab Mol Biol Exercise, Sao Paulo - Brazil
[2] I, Yale Sch Med, Dept Internal Med, New Haven, CT - USA
[3] Univ Estadual Campinas, OCRC Obes & Comorbid Res Ctr, UNICAMP, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM; v. 320, n. 3, p. E488-E495, MAR 2021.
Web of Science Citations: 0
Abstract

Brown adipose tissue (BAT) has been encouraged as a potential treatment for obesity and comorbidities due to its thermogenic activity capacity and contribution to energy expenditure. Some interventions such as cold and beta-adrenergic drugs are able to activate BAT thermogenesis as well as promote differentiation of white adipocytes into brown-like cells (browning), enhancing the thermogenic activity of these cells. In this mini-review, we discuss new mechanisms related to BAT and energy expenditure. In this regard, we will also discuss recent studies that have revealed the existence of important secretory molecules from BAT ``batokines{''} that act in autocrine, paracrine, and endocrine mechanisms, which in turn may explain some of the beneficial roles of BAT on whole body glucose and fat metabolism. Finally, we will discuss new insights related to BAT thermogenesis with an additional focus on the distinct features of BAT metabolism between rodents and humans. (AU)

FAPESP's process: 19/00227-1 - Effects mediated by the exercise and metformin on rock protein and the regulation of lipogenesis and glucose production in the liver of rodents with celiac disease
Grantee:José Rodrigo Pauli
Support Opportunities: Scholarships abroad - Research
FAPESP's process: 19/11338-9 - The effects of physical exercise on IP3 in the liver of obese mice
Grantee:Rafael Calais Gaspar
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 18/07568-6 - The role of physical exercise on Rock protein pathway, and lipogenic regulation and gluconeogenesis in the liver of aged rats.
Grantee:Vitor Rosetto Muñoz
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/20872-6 - Effects of physical exercise on Rock protein signaling pathway, and lipogenic regulation and gluconeogenesis in the liver of aged rats
Grantee:José Rodrigo Pauli
Support Opportunities: Regular Research Grants