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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis

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Author(s):
dos Santos, Paulo Victor P. [1] ; Ribeiro, Camila M. [2] ; Pavan, Fernando R. [2] ; Corbi, Pedro P. [3] ; Bergamini, Fernando R. G. [3, 4] ; Carvalho, Marcos A. [3, 5] ; D'Oliveria, Kaique A. [1] ; Cuin, Alexandre [1]
Total Authors: 8
Affiliation:
[1] Fed Univ Juiz de Fora UFJF, Inst Exact Sci, Dept Chem, LQBin Lab BioInorgan Chem, BR-36036330 Juiz De Fora, MG - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, TB Res Lab Araraquara, Araraquara, SP - Brazil
[3] Univ Campinas UNICAMP, Inst Chem, BR-13083970 Campinas, SP - Brazil
[4] Fed Univ Uberlandia UFU, Inst Chem, Lab Synth Bioinspired Mol, Uberlandia, MG - Brazil
[5] Fed Univ Mato Grosso UFMT, Dept Chem, BR-78060900 Cuiaba, MT - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Molecular Structure; v. 1234, JUN 15 2021.
Web of Science Citations: 0
Abstract

In the present work, synthesis, characterization and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes are described. The compounds were characterized by elemental analysis, IR and NMR spectroscopic measurements, molar conductivity assays and powder diffraction X ray studies. Some of the synthesized compounds have shown minimum inhibitory concentration (MIC90) values against M. tuberculosis H37Rv (ATCC 27294) lower than 0.098 mu g/mL, while the cytotoxic activity assays over MRC-5 cells reveled that all compounds present selectivity indexes higher than 27. Furthermore, N-acylhydrazones compounds showed promising activities even against multidrug-resistant clinical strains of M. tuberculosis. (C) 2021 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 18/12062-4 - Synthesis, characterization and studies of interaction with biomolecules of metal complexes containing biologically active ligands: a strategy in the preparation of new agents with antibacterial and antiviral activities
Grantee:Pedro Paulo Corbi
Support Opportunities: Regular Research Grants
FAPESP's process: 18/00163-0 - Development and search of new antimicrobials against Tuberculosis: from screening to pre-clinical studies in vivo
Grantee:Fernando Rogério Pavan
Support Opportunities: Regular Research Grants