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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ageing changes testes and epididymis blood flow without altering biometry and echodensity in dogs

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Author(s):
Brito, Maira Morales [1] ; da Rosa Filho, Roberto Rodrigues [1] ; Agostini Losano, Joao Diego [1] ; Vannucchi, Camila Infantosi [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Anim Reprod, Rua Prof Orlando Marques de Paiva 87, BR-05508270 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Animal Reproduction Science; v. 228, MAY 2021.
Web of Science Citations: 0
Abstract

Senescence leads to deleterious effects in testicular function, sperm quality and fertility in dogs. There, however, are no consistent results of vascular changes in the testes and epididymis during natural ageing in dogs. The aim of this study, therefore, was to compare testes and epididymis blood flow, biometry and echodensity between young and senile dogs. Ten young dogs (1-4 years) and eight senile dogs (over 7 years) were selected and assigned to two experimental groups: Young Group and Senile Group. Dogs were evaluated using testicular and epididymis B-mode (dimensions and echodensity) and Doppler ultrasonography (tissue perfusion parameters and blood flow velocity of the testicular artery). There were no differences between experimental groups for the echographic evaluation of testicular and epididymis parenchyma and biometric variables. The dogs in the Young Group had greater (P = 0.02) testes vascularization score and greater (P = 0.06) testicular artery blood flow velocity than those in the Senile Group. Furthermore, the older dogs had a greater (P = 0.06) pulsatility index of the testicular artery than those in the Young Group. Ageing, therefore, seems to cause natural hemodynamical changes to the testicular artery, resulting in reduced blood flow (ischemia) and tissue damage. Testes and epididymis vascular characteristics, therefore, may represent the causal factors for changes in spermatogenesis and, as a consequence, negatively affect the sperm quality of older dogs. In conclusion, senescence alters testicular artery blood flow and vascularization of the testes, without changing testicular and epididymis ultrasonographic dimensions and echodensity in dogs. (AU)

FAPESP's process: 17/06859-4 - Study of spermatogenesis and sperm maturation in senile dogs
Grantee:Maíra Morales Brito
Support Opportunities: Scholarships in Brazil - Doctorate