| Full text | |
| Author(s): Show less - |
Bispo, Saloe
[1]
;
Farias, Ticiana D. J.
[1]
;
de Araujo-Souza, Patricia Savio
[2, 3]
;
Cintra, Ricardo
[4]
;
Santos, Hellen Geremias dos
[1]
;
Jorge, Natasha Andressa Nogueira
[5, 6]
;
Castro, Mauro Antonio Alves
[7]
;
Wajnberg, Gabriel
[5, 8]
;
Scherer, Nicole de Miranda
[9]
;
Genta, Maria Luiza Nogueira Dias
[10]
;
Carvalho, Jesus Paula
[10]
;
Villa, Luisa Lina
[11, 12]
;
Sichero, Laura
[12]
;
Passetti, Fabio
[1, 5]
Total Authors: 14
|
| Affiliation: Show less - | [1] Fiocruz MS, Inst Carlos Chagas, Curitiba, Parana - Brazil
[2] Univ Fed Parana, Dept Genet, Lab Immunogenet & Histocompatibil, Curitiba, Parana - Brazil
[3] Univ Fed Fluminense UFF, Inst Biol, Dept Immunobiol, Niteroi, RJ - Brazil
[4] Univ Sao Paulo, Inst Quim, Dept Biochem, Sao Paulo - Brazil
[5] Fiocruz MS, Inst Oswaldo Cruz, Rio De Janeiro - Brazil
[6] Univ Leipzig, Dept Comp Sci, Bioinformat Grp, Interdisciplinary Ctr Bioinformat, Leipzig - Germany
[7] Univ Fed Parana, Bioinformat & Syst Biol Lab, Curitiba, Parana - Brazil
[8] Atlant Canc Res Inst, Moncton, NB - Canada
[9] Brazilian Natl Canc Inst INCA, Div Expt & Translat Res, Lab Bioinformat & Computat Biol, Rio De Janeiro - Brazil
[10] Univ Sao Paulo, Fac Med, Dept Obstet & Gynecol, Discipline Gynecol, Hosp Clin, Inst Canc Estado Sao, Sao Paulo - Brazil
[11] Univ Sao Paulo, Fac Med, Dept Radiol & Oncol, Sao Paulo - Brazil
[12] Univ Sao Paulo FMUSP HC, Fac Med, Hosp Clin, Ctr Translat Res Oncol, Inst Canc Estado Sao Paulo, Sao Paulo - Brazil
Total Affiliations: 12
|
| Document type: | Journal article |
| Source: | FRONTIERS IN ONCOLOGY; v. 11, MAY 19 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Squamous cell carcinoma (SCC) and adenocarcinoma (ADC) are the most common histological types of cervical cancer (CC). The worse prognosis of ADC cases highlights the need for better molecular characterization regarding differences between these CC types. RNA-Seq analysis of seven SCC and three ADC human papillomavirus 16-positive samples and the comparison with public data from non-tumoral human papillomavirus-negative cervical tissue samples revealed pathways exclusive to each histological type, such as the epithelial maintenance in SCC and the maturity-onset diabetes of the young (MODY) pathway in ADC. The transcriptional regulatory network analysis of cervical SCC samples unveiled a set of six transcription factor (TF) genes with the potential to positively regulate long non-coding RNA genes DSG1-AS1, CALML3-AS1, IGFL2-AS1, and TINCR. Additional analysis revealed a set of MODY TFs regulated in the sequence predicted to be repressed by miR-96-5p or miR-28-3p in ADC. These microRNAs were previously described to target LINC02381, which was predicted to be positively regulated by two MODY TFs upregulated in cervical ADC. Therefore, we hypothesize LINC02381 might act by decreasing the levels of miR-96-5p and miR-28-3p, promoting the MODY activation in cervical ADC. The novel TF networks here described should be explored for the development of more efficient diagnostic tools. (AU) | |
| FAPESP's process: | 08/57889-1 - Institute of Science and Technology to study Diseases Associated with Papillomavirus |
| Grantee: | Luisa Lina Villa |
| Support Opportunities: | Research Projects - Thematic Grants |