Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multifocal Analysis of Acute Pain After Third Molar Removal

Full text
Author(s):
Show less -
Weckwerth, Giovana Maria [1] ; Dionisio, Thiago Jose [1] ; Costa, Yuri Martins [2] ; Zupelari-Goncalves, Paulo [1] ; Oliveira, Gabriela Moraes [1] ; Torres, Elza Araujo [1] ; Bonjardim, Leonardo Rigoldi [1] ; Faria, Flavio Augusto Cardoso [1] ; Calvo, Adriana Maria [1] ; Moore, Troy [3] ; Absher, Devin Michael [4] ; Santos, Carlos Ferreira [1]
Total Authors: 12
Affiliation:
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP - Brazil
[2] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Biosci, Piracicaba - Brazil
[3] Kailos Genet Inc, HudsonAlpha Inst Biotechnol, Huntsville, AL - USA
[4] HudsonAlpha Inst Biotechnol, Huntsville, AL - USA
Total Affiliations: 4
Document type: Journal article
Source: FRONTIERS IN PHARMACOLOGY; v. 12, APR 15 2021.
Web of Science Citations: 0
Abstract

Background: To analyze the pain modulation capacity profile in a Brazilian population, the relationship between opioid receptor (OPRM1) and Catechol-O-methyltransferase (COMT) 1polymorphisms and pain modulation capacity was determined through preoperative pain modulation tests and acute postoperative pain control evaluation, swelling, and trismus in 200 volunteers undergoing lower third molar removal. Methods: Psychologic and clinical parameters were measured. Patient DNA was sequenced for single nucleotide polymorphisms in OPRM1 and COMT, and the salivary concentration of interleukin (IL)-2 (IL)-6, interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha was evaluated. Primary outcomes were the influence of all predictors on the fluctuation of pain intensity using a visual analogue scale (VAS), and swelling and trismus on the 2nd and 7th postoperative days. Preoperative pain modulation capacity (CPM), pain catastrophizing scale (PCS), body mass index (BMI), and surgery duration and difficulty were evaluated. Results: Salivary concentration of IFN-gamma and IL-2 as well as the duration of surgery influenced the fluctuation of postoperative pain in the VAS, and in the sum of the differences in pain intensity test at 8, 48, and 96 h. BMI influenced swelling, while both BMI and COMT haplotype influenced trismus on the 2nd postoperative day. Conclusion: Polymorphisms in COMT, salivary concentrations of IL-2 and IFN-gamma, BMI, and duration of surgery were predictors for pain fluctuation, swelling, and trismus on the 2nd day after lower third molar extraction. This therapy was effective in controlling inflammatory symptomatology after lower third molar extraction and ibuprofen was well tolerated by patients. (AU)

FAPESP's process: 17/12725-0 - Model of pharmakinetics/pharmacodynamics (PK/PD) on the influence of P450 genetic polymorphism (CYP2C9) of non-steroidal anti-inflammatory drugs and main metabolics from saliva samples through LCMS/MS and its role on prescription personalization
Grantee:Adriana Maria Calvo
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 18/04157-5 - Clinical pharmacogenetics of ibuprofen enantiomers after lower third molar surgeries
Grantee:Giovana Maria Weckwerth
Support Opportunities: Scholarships abroad - Research Internship - Doctorate