an maternal exposure to tamoxifen compromise sperm... - BV FAPESP
Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

an maternal exposure to tamoxifen compromise sperm and behavioural parameters of male rat offspring

Full text
Author(s):
Manoel, Beatriz de Matos [1] ; Moreira, Suyane da Silva [2] ; Zampieri, Gabriela Morelli [2] ; Pinheiro, Luisa Machado [2] ; Jorge, Barbara Campos [2] ; Casali Reis, Ana Carolina [2] ; Leite Kassuya, Candida Aparecida [1] ; Arena, Arielle Cristina [2, 3]
Total Authors: 8
Affiliation:
[1] Univ Fed Grande Dourados UFGD, Fac Hlth Sci, Dourados, MS - Brazil
[2] Univ Estadual Paulista UNESP, Inst Biosci Botucatu, Dept Struct & Funct Biol, Dist Rubiao Jr S-N, Caixa Postal 510, BR-18618970 Botucatu, SP - Brazil
[3] Univ Estadual Paulista UNESP, Inst Biosci Botucatu, Ctr Toxicol Assistance CEATOX, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REPRODUCTIVE TOXICOLOGY; v. 108, p. 1-9, MAR 2022.
Web of Science Citations: 0
Abstract

Tamoxifen, a selective non-steroidal estrogen receptor modulator, is the standard adjuvant endocrine treatment for breast cancer. Since information on the risk of using tamoxifen during pregnancy is still scarce, this study evaluated whether the in utero and lactational treatment with this drug could compromise reproductive and behavioural parameters in male offspring. Pregnant Wistar rats were exposed to three doses of tamoxifen (0.12; 0.6; 3 mu g/kg), by gavage, from gestational day 15 to lactational day 20. Tamoxifen exposure did not alter the anogenital distance in the male offspring; however, there was a significant increase in the body weight in the 0.12 mu g/kg dose and a decrease in the 0.6 mu g/kg dose. The male offspring treated with the highest dose exhibited a delay in the onset of puberty, evidenced by an increase in the age of preputial separation. Regarding sperm parameters, there was an increase in the sperm count in the cauda epididymis in the intermediate and highest dose groups, in addition to an increase in the number of static sperm and a decrease in the progressive sperm in the same groups. Moreover, an increase in the number of hyperplasia of the epithelial clear cells was observed in the epididymis. In conclusion, the present study demonstrated that maternal exposure to tamoxifen compromised the installation of puberty of the male offspring and the maturation of the epididymis, affecting sperm storage and motility in the adult life. (AU)

FAPESP's process: 19/25357-5 - Influence of tamoxifen in utero and lactation exposure: repercussion on reproductive parameters in adulthood in male rats
Grantee:Gabriela Morelli Zampieri
Support Opportunities: Scholarships in Brazil - Scientific Initiation