| Full text | |
| Author(s): Show less - |
Cardoso, T. F.
;
Bruscadin, J. J.
;
Afonso, J.
;
Petrini, J.
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Andrade, B. G. N.
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de Oliveira, P. S. N.
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Malheiros, J. M.
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Rocha, M. I. P.
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Zerlotini, A.
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Ferraz, J. B. S.
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Mourao, G. B.
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Coutinho, L. L.
;
Regitano, L. C. A.
Total Authors: 13
|
| Document type: | Journal article |
| Source: | Mammalian Genome; v. 33, n. 4, p. 10-pg., 2022-07-11. |
| Abstract | |
Cis-acting effects of noncoding variants on gene expression and regulatory molecules constitute a significant factor for phenotypic variation in complex traits. To provide new insights into the impacts of single-nucleotide polymorphisms (SNPs) on transcription factors (TFs) and transcription cofactors (TcoF) coding genes, we carried out a multi-omic analysis to identify cis-regulatory effects of SNPs on these genes' expression in muscle and describe their association with feed efficiency-related traits in Nelore cattle. As a result, we identified one SNP, the rs137256008C > T, predicted to impact the EEF1A1 gene expression (beta = 3.02; P-value = 3.51E-03) and the residual feed intake trait (beta = - 3.47; P-value = 0.02). This SNP was predicted to modify transcription factor sites and overlaps with several QTL for feed efficiency traits. In addition, co-expression network analyses showed that animals containing the T allele of the rs137256008 SNP may be triggering changes in the gene network. Therefore, our analyses reinforce and contribute to a better understanding of the biological mechanisms underlying gene expression control of feed efficiency traits in bovines. The cis-regulatory SNP can be used as biomarker for feed efficiency in Nelore cattle. (AU) | |
| FAPESP's process: | 18/11953-2 - Variations in regulatory regions associated with meat production and quality characteristics in the Nelore breed |
| Grantee: | Tainã Figueiredo Cardoso |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 12/23638-8 - Molecular basis of meat quality in Nelore beef cattle |
| Grantee: | Luciana Correia de Almeida Regitano |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/04089-2 - The Nelore hologenome: implications in beef quality and feed efficiency |
| Grantee: | Luciana Correia de Almeida Regitano |
| Support Opportunities: | Research Grants - eScience and Data Science Program - Thematic Grants |