Omega-3 pleiad: The multipoint anti-inflammatory strategy

Author(s)

Batista, Ellencristina da Silva ; Branco Ramos Nakandakari, Susana Castelo ; Ramos da Silva, Adelino Sanchez ; Pauli, Jose Rodrigo ; de Moura, Leandro Pereira ; Ropelle, Eduardo Rochete ; Camargo, Enilton A. ; Cintra, Dennys Esper

• Document type: Journal article
• Source: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION; v. N/A, p. 16-pg., 2022-11-10.

Abstract

Omega 3 (omega 3) fatty acids have been described since the 1980s as promising anti-inflammatory substances. Prostaglandin and leukotriene modulation were exhaustively explored as the main reason for omega 3 beneficial outcomes. However, during the early 2000s, after the human genome decoding advent, the nutrigenomic approaches exhibited an impressive plethora of omega 3 targets, now under the molecular point of view. Different G protein-coupled receptors (GPCRs) recognizing omega 3 and its derivatives appear to be responsible for blocking inflammation and insulin-sensitizing effects. A new class of omega 3-derived substances, such as maresins, resolvins, and protectins, increases omega 3 actions. Inflammasome disruption, the presence of GPR120 on immune cell surfaces, and intracellular crosstalk signaling mediated by PPAR gamma compose the last discoveries regarding the multipoint anti-inflammatory targets for this nutrient. This review shows a detailed mechanistic proposal to understand omega 3 fatty acid action over the inflammatory environment in the background of several chronic diseases. (AU)

• FAPESP's process: 20/13443-1 - Implications of aerobic exercise on the Notch 1 signaling pathway and regulation of lipogenesis and gluconeogenesis in the liver
• Grantee: José Rodrigo Pauli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/13210-0 - Evaluation of the omega-3's molecular mechanism of action in the early-onset of Alzheimer Disease associated to obesity and type 2 Diabetes in mice: the role GPR120
• Grantee: Dennys Esper Corrêa Cintra
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/13168-3 - The influence of GPR120 in the immune system
• Grantee: Susana Castelo Branco Ramos Nakandakari
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)