| Full text | |
| Author(s): |
Porto, Ana Carolina
;
Blumetti, Tatiana Pinto
;
Calsavara, Vinicius Fernando
;
Torrezan, Giovana Tardin
;
Andrade de Paula, Claudia Alessandra
;
Lellis, Rute
;
Duprat Neto, Joao Pedreira
;
Carraro, Dirce Maria
;
Tavoloni Braga, J. Casagrande
Total Authors: 9
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 12, n. 1, p. 10-pg., 2022-09-05. |
| Abstract | |
Scalp melanoma (SM) has a worse prognosis than melanoma in other locations likely because of late diagnosis due to hair coverage, difficulties in interpreting dermoscopy findings, and its unique molecular profile. We aimed to describe the clinical, histopathological, molecular, and dermoscopic patterns of SM and its relation to androgenetic alopecia/elastosis at the tumor site. Through a retrospective cross-sectional study, we identified all SM diagnosed at the A.C.Camargo Cancer Center between 2008 and 2018. In all, 48 SM were analyzed: 45.8% of which exhibited moderate/severe androgenetic alopecia and 54.1% exhibited elastosis. Androgenetic alopecia/elastosis at the site of the SM was associated with older age (p < 0.001), chronic sun damage (p < 0.001), lentigo maligna subtype (p = 0.029), and photodamaged dermoscopic pattern (p < 0.001). Additionally, 41 cases were evaluated with a 14-gene panel: 53.7% displayed mutations and 46.3% were wild-type. BRAF mutations were most common (77%), with BRAF V600K being more frequent (50%) than BRAF V600E (31.2%). The NF1 gene was evaluated in 40 samples, of which 20% exhibited mutations. SM presents differently in areas covered by hair compared to in areas with androgenetic alopecia. Patients without alopecia may have higher Breslow thickness due to late diagnosis because of hair concealment. The high frequency of detrimental mutations can also explain the poor prognosis of SM. (AU) | |
| FAPESP's process: | 19/05098-5 - Scalp melanoma: epidemiological, dermatoscopic, histopathological and molecular differences between melanoma located in area covered by hair and melanoma located in exposed area of bald patients |
| Grantee: | Juliana Casagrande Tavoloni Braga |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/50943-1 - INCT 2014: on Oncogenomics and Therapeutic Inovations |
| Grantee: | Dirce Maria Carraro |
| Support Opportunities: | Research Projects - Thematic Grants |