| Full text | |
| Author(s): |
de Oliveira, Isadora Sousa
;
Pucca, Manuela Berto
;
Ferreira, Isabela Gobbo
;
Cerni, Felipe Augusto
;
Jacob, Beatriz de Cassia da Silva
;
Wiezel, Gisele Adriano
;
Pinheiro-Junior, Ernesto Lopes
;
Cordeiro, Francielle Almeida
;
Figueiredo Bordon, Karla de Castro
;
Arantes, Eliane Candiani
Total Authors: 10
|
| Document type: | Journal article |
| Source: | Toxicon; v. 217, p. 10-pg., 2022-08-23. |
| Abstract | |
Phosphodiesterases (PDEs) constitute an enzyme group able to hydrolyze nucleic acids as well as some second messengers. Due to this ability and their expression in several human tissues and organs, PDEs can control a gamut of physiological processes. They are also involved in some pathological conditions, such as Alzheimer's disease and erectile dysfunction. PDEs are also expressed in snake venom glands, being called snake venoms phosphodiesterases, or simply svPDEs. The occurrence of these enzymes has already been reported in crotalid, elapid and viperid venoms, such as Crotalus, Naja and Trimeresurus, respectively, but not all of them have been characterized concerning their structure, activity and function. In this review, we are addressing general char-acteristics of svPDEs, in addition to their structural, biochemical and functional characteristics, and we also report some potential applications of svPDEs. (AU) | |
| FAPESP's process: | 17/00586-6 - Characterization of a phospholipase A2 inhibitor from the Crotalus durissus terrificus venom gland: a possible adjuvant in the antivenom therapy |
| Grantee: | Gisele Adriano Wiezel |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 20/13176-3 - Human monoclonal antibodies (scFv) discovery with cross-reactivity and pH-dependent to metalloproteases from Bothrops spp |
| Grantee: | Isadora Sousa de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |