Role of microRNAs in B-Cell Compartment: Development, Proliferation and Hematological Diseases

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Author(s):	Souza, Olivia Fonseca ; Popi, Ana Flavia Total Authors: 2
Document type:	Journal article
Source:	BIOMEDICINES; v. 10, n. 8, p. 17-pg., 2022-08-01.
Abstract
B-cell development is a very orchestrated pathway that involves several molecules, such as transcription factors, cytokines, microRNAs, and also different cells. All these components maintain the ideal microenvironment and control B-cell differentiation. MicroRNAs are small non-coding RNAs that bind to target mRNA to control gene expression. These molecules could circulate in the body in a free form, protein-bounded, or encapsulated into extracellular vesicles, such as exosomes. The comprehension of the role of microRNAs in the B-cell development was possible based on microRNA profile of each B-cell stage and functional studies. Herein, we report the knowledge about microRNAs in the B-cell the differentiation, proliferation, and also in hematological malignancies. (AU)

FAPESP's process:	19/27009-4 - MicroRNAs and apoptosis evaluation in B-1 cells progenitors along aging
Grantee:	Olívia Fonseca Souza
Support Opportunities:	Scholarships in Brazil - Doctorate (Direct)


FAPESP's process:	21/05377-1 - Alterations in the miRNA profile and its impact on the survival of B-1 cells and their precursors during aging
Grantee:	Ana Flavia Popi
Support Opportunities:	Regular Research Grants