The role of cellular quiescence in cancer - beyond a quiet passenger

Author(s)

Tomasin, Rebeka ; Bruni-Cardoso, Alexandre

• Document type: Journal article
• Source: Journal of Cell Science; v. 135, n. 15, p. 11-pg., 2022-08-01.

Abstract

Quiescence, the ability to temporarily halt proliferation, is a conserved process that initially allowed survival of unicellular organisms during inhospitable times and later contributed to the rise of multicellular organisms, becoming key for cell differentiation, size control and tissue homeostasis. In this Review, we explore the concept of cancer as a disease that involves abnormal regulation of cellular quiescence at every step, from malignant transformation to metastatic outgrowth. Indeed, disrupted quiescence regulation can be linked to each of the so-called 'hallmarks of cancer'. As we argue here, quiescence induction contributes to immune evasion and resistance against cell death. In contrast, loss of quiescence underlies sustained proliferative signalling, evasion of growth suppressors, pro-tumorigenic inflammation, angiogenesis and genomic instability. Finally, both acquisition and loss of quiescence are involved in replicative immortality, metastasis and deregulated cellular energetics. We believe that a viewpoint that considers quiescence abnormalities that occur during oncogenesis might change the way we ask fundamental questions and the experimental approaches we take, potentially contributing to novel discoveries that might help to alter the course of cancer therapy. (AU)

• FAPESP's process: 19/26767-2 - Proteostasis regulation of MST2 in the Hippo pathway
• Grantee: Alexandre Bruni Cardoso
• Support Opportunities: Regular Research Grants