Mastoparans: A Group of Multifunctional alpha-Helical Peptides With Promising Therapeutic Properties

Author(s)

de Santana, Carlos Jose Correia ; Pires Jr, Osmindo Rodrigues ; Fontes, Wagner ; Palma, Mario Sergio ; Castro, Mariana S.

• Document type: Journal article
• Source: FRONTIERS IN MOLECULAR BIOSCIENCES; v. 9, p. 19-pg., 2022-06-24.

Abstract

Biologically active peptides have been attracting increasing attention, whether to improve the understanding of their mechanisms of action or in the search for new therapeutic drugs. Wasp venoms have been explored as a remarkable source for these molecules. In this review, the main findings on the group of wasp linear cationic alpha-helical peptides called mastoparans were discussed. These compounds have a wide variety of biological effects, including mast cell degranulation, activation of protein G, phospholipase A(2), C, and D activation, serotonin and insulin release, and antimicrobial, hemolytic, and anticancer activities, which could lead to the development of new therapeutic agents. (AU)

• FAPESP's process: 16/16212-5 - Natural proteopeptides from the Brazilian fauna, flora and microbiota as potential models for the rational development of new drugs of therapeutic use: isolation, structure elucidation, chemical synthesis and functional activity assays
• Grantee: Mario Sergio Palma
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants