Consequences of the exposome to gestational diabetes mellitus

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Rudge, Marilza V. C. ; Alves, Fernanda C. B. ; Hallur, Raghavendra L. S. ; Oliveira, Rafael G. ; Vega, Sofia ; Reyes, David R. A. ; Floriano, Juliana F. ; Prudencio, Caroline B. ; Garcia, Gabriela A. ; Reis, Fabiana V. D. S. ; Emanueli, Costanza ; Fuentes, Gonzalo ; Cornejo, Marcelo ; Toledo, Fernando ; Valenzuela-Hinrichsen, Andres ; Guerra, Catalina ; Grismaldo, Adriana ; Valero, Paola ; Barbosa, Angelica M. P. ; Sobrevia, Luis

• Document type: Journal article
• Source: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS; v. 1867, n. 2, p. 14-pg., 2023-02-01.

Abstract

The exposome is the cumulative measure of environmental influences and associated biological responses throughout the lifespan, including those from the environment, diet, behaviour, and endogenous processes. The exposome concept and the 2030 Agenda for the Sustainable Development Goals (SDGs) from the United Nations are the basis for understanding the aetiology and consequences of non-communicable diseases, including gestational diabetes mellitus (GDM). Pregnancy may be developed in an environment with adverse factors part of the immediate internal medium for fetus development and the external medium to which the pregnant woman is exposed. The placenta is the interface between maternal and fetal compartments and acts as a protective barrier or easing agent to transfer exposome from mother to fetus. Under and over-nutrition in utero, exposure to adverse environmental pollutants such as heavy metals, endocrine-disrupting chemicals, pesticides, drugs, pharmaceuticals, lifestyle, air pollutants, and tobacco smoke plays a determinant role in the development of GDM. This phenomenon is worsened by metabolic stress postnatally, such as obesity which increases the risk of GDM and other diseases. Clinical risk factors for GDM development include its aetiology. It is proposed that knowledge-based interventions to change the potential interdependent ecto-exposome and endo-exposome could avoid the occurrence and consequences of GDM. (AU)

• FAPESP's process: 18/02979-8 - Prospective cohort of biochemical, protein and immunohistochemical markers of muscle fiber and extracellular matrix of the rectus abdominis muscle of Hyperglycemia and gestational-specific urinary incontinence as predictor of UI 6-12 months post-cesarean
• Grantee: Raghavendra Hallur Lakshmana Shetty
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/01743-5 - The new gestational triad: hyperglycemia, urinary incontinence (UI) and biomolecular profile as a long-term predictor for UI: a prospective cohort study: translational research with biodevice with stem cells for muscle regeneration in diabetic rats
• Grantee: Marilza Vieira Cunha Rudge
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/26305-6 - Skeletal muscle organoid of pregnant women with Gestational Hyperglycemia and pregnancy-specific Urinary Incontinence as funcional 3D model to research biomarkers of Gestational Hyperglycemic Myopathy
• Grantee: Rafael Guilen de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/10665-6 - Effectiveness of the pelvic floor muscle training in aquatic ambient on pelvic floor muscle function and pregnancy specific urinary incontinence in pregnant women with Gestational Diabetes Mellitus: a feasibility study to randomized controlled trial
• Grantee: Caroline Baldini Prudencio
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/21783-4 - Gestational triad cohort: hyperglycemia, urinary incontinence and clinical, molecular and omic profile of hyperglycemic myopathy in predicting incontinence and muscle dysfunction and translational research with biodevice for muscle regeneration in rats
• Grantee: Juliana Ferreira Floriano
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/05710-2 - Prospective cohort of the omic biomarkers of the abdominal rectus muscle of pregnant women with hyperglycemia and pregnancy-specific urinary incontinence as predictors of urinary incontinence 6-12 months postpartum.
• Grantee: Fernanda Cristina Bérgamo Alves
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/10661-8 - Gestational triad hyperglycemia cohort, urinary incontinence and clinical profile, molecular and omic of hyperglycemic myopathy in the prediction of incontinence and muscle dysfunction and translational research with biodevic for muscle regeneration in ra
• Grantee: David Rafael Abreu Reyes
• Support Opportunities: Scholarships in Brazil - Post-Doctoral