| Full text | |
| Author(s): |
Meneguin, Andreia Bagliotti
;
Barud, Hernane da Silva
;
Sabio, Rafael Miguel
;
de Sousa, Paula Zanin
;
Manieri, Karyn Fernanda
;
Pedro de Freitas, Luis Alexandre
;
Pacheco, Guilherme
;
Alonso, Jovan Duran
;
Chorilli, Marlus
Total Authors: 9
|
| Document type: | Journal article |
| Source: | Carbohydrate Polymers; v. 249, p. 13-pg., 2020-12-01. |
| Abstract | |
Defibrillation of bacterial cellulose by ultra-refining was efficient to release nanofibers (BCNF) which were spray dried with the matrices formers mannitol (MN), maltodextrin or hydroxypropylmethylcellulose. The best microsystem comprised the association of BCNF and MN, so the selected microparticles were loaded with diclofenac sodium or caffeine. Depending on the proportion of BCNF, the nanofibers collapse promoted by spray drying can occur onto surface or into microparticles core, leading to different release behaviors. Samples showed pH-dependent drug release, so the microsystem developed with the lowest BCNF concentration showed important trend to gastroresistance. Caffeine was spray dried as a free drug and for this reason it was devoid of any control over release rates. The set of results showed BCNF can be considered an interesting and potential pharmaceutical excipient for lipophilic drugs. Beyond that, BCNF association with MN can lead to novel enteric drug delivery systems based on natural polymers. (AU) | |
| FAPESP's process: | 18/25512-8 - Biocelulose-based Cell Culture Platform |
| Grantee: | Hernane da Silva Barud |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/08435-4 - Biocellulose nanofibers: a new generation of materials for applications in drug delivery |
| Grantee: | Andréia Bagliotti Meneguin |
| Support Opportunities: | Research Grants - Innovative Research in Small Business - PIPE |