Myosin motors on the pathway of viral infections

Author(s)

Matozo, Tais ; Kogachi, Leticia ; de Alencar, Bruna Cunha

• Document type: Journal article
• Source: CYTOSKELETON; v. 79, n. 6-8, p. 23-pg., 2022-07-22.

Abstract

Molecular motors are microscopic machines that use energy from adenosine triphosphate (ATP) hydrolysis to generate movement. While kinesins and dynein are molecular motors associated with microtubule tracks, myosins bind to and move on actin filaments. Mammalian cells express several myosin motors. They power cellular processes such as endo- and exocytosis, intracellular trafficking, transcription, migration, and cytokinesis. As viruses navigate through cells, they may take advantage or be hindered by host components and machinery, including the cytoskeleton. This review delves into myosins' cell roles and compares them to their reported functions in viral infections. In most cases, the previously described myosin functions align with their reported role in viral infections, although not in all cases. This opens the possibility that knowledge obtained from studying myosins in viral infections might shed light on new physiological roles for myosins in cells. However, given the high number of myosins expressed and the variety of viruses investigated in the different studies, it is challenging to infer whether the interactions found are specific to a single virus or can be applied to other viruses with the same characteristics. We conclude that the participation of myosins in viral cycles is still a largely unexplored area, especially concerning unconventional myosins. (AU)

• FAPESP's process: 14/23225-0 - Role of myosins in dendritic cell mediated trans-infection of HIV-1 and in HIV-1 replication in macrophages
• Grantee: Bruna Cunha Gondim de Alencar
• Support Opportunities: Research Grants - Young Investigators Grants