Concise two-step chemical synthesis of molnupiravir

Author(s)

Pereira, Vinicius R. D. ; Bezerra, Marco A. M. ; Gomez, Mauro R. B. P. ; Martins, Guilherme M. ; da Silva, Adilson D. ; de Oliveira, Kleber T. ; de Souza, Rodrigo O. M. A. ; Amarante, Giovanni W.

• Document type: Journal article
• Source: RSC ADVANCES; v. 12, n. 46, p. 5-pg., 2022-10-17.

Abstract

A concise synthesis of molnupiravir in a one-pot two-step approach starting from uridine is described. Formally, herein, two sets of one-pot two-reaction steps introducing simplicity for purifications and using chemically available reagents are presented. In this context, molnupiravir was obtained in up to 68% overall yield and multigram-scale. In addition, HPLC analysis showed the molnupiravir purity above 99%. (AU)

• FAPESP's process: 22/00074-3 - Regioselective fluorination of N-heterocycles using electrosynthesis and continuous flow conditions
• Grantee: Guilherme Ariel Machado Martins
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/27176-8 - Asymmetric photocatalysis applied to the synthesis of Brivaracetam: synthetic approaches employing enabling technologies for chemical synthesis
• Grantee: Kleber Thiago de Oliveira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/06874-6 - Applications of technologies and synthetic methodologies developed under continuous flow conditions at LQBO-UFSCar for the preparation of molecules with biological activities and APIs
• Grantee: Kleber Thiago de Oliveira
• Support Opportunities: Regular Research Grants