| Full text | |
| Author(s): |
Kraemer, Mauricio Beitia
;
Silva, Karen Christine
;
Kraemer, Camila Cunha Franca
;
Pereira, Juliana Silva
;
dos Reis, Ivan Gustavo Masseli
;
Priolli, Denise Goncalves
;
Messias, Leonardo Henrique Dalcheco
Total Authors: 7
|
| Document type: | Journal article |
| Source: | FRONTIERS IN PHYSIOLOGY; v. 13, p. 11-pg., 2022-08-24. |
| Abstract | |
This study comprises two complementary experiments with athymic Balb/c (Nu/Nu) mice. In experiment 1, the aim was to verify the reproducibility of the peak velocity (V-Peak) determined from the incremental test. The second experiment aimed to assess the V-Peak sensitivity to prescribe and detect modulations of the physical training in athymic nude mice. Sixteen mice were submitted to two incremental treadmill tests separated by 48-h (Experiment 1). The test consisted of an initial warm-up of 5 minutes. Subsequently, animals initiated the tests at 8 m min(-1) with increments of 2 m min(-1) every 3 minutes. The V-Peak was determined as the highest velocity attained during the protocol. In experiment 2, these animals were randomly allocated to an exercise group (EG) or a control group (CG). The training protocol consisted of 30-min of treadmill running at 70% of the V-Peak five times a week for 4 weeks. High indexes of reproducibility were obtained for V-Peak (Test = 19.7 +/- 3.6 m min(-1); Retest = 19.2 +/- 3.4 m min(-1); p = 0.171; effect size = 0.142; r = 0.90). Animals from the EG had a significant increase of V-Peak (Before = 18.4 +/- 2.7 m min(-1); After = 24.2 +/- 6.0 m min(-1); p = 0.023). Conversely, a significant decrease was observed for the CG (Before = 21.1 +/- 3.9 m min(-1); After = 15.9 +/- 2.7 m min(-1); p = 0.038). The V-Peak is a valid parameter for exercise prescription in studies involving athymic nude mice. (AU) | |
| FAPESP's process: | 19/23592-7 - Vasohibin aptamer (VASH-aptamer): a potential theranostic agent in colorectal cancer |
| Grantee: | Denise Gonçalves Priolli |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/21471-5 - VASOHIBIN: POTENTIAL TARGETING INHIBITOR OF ANGIOGENESIS IN COLORECTAL CANCER |
| Grantee: | Denise Gonçalves Priolli |
| Support Opportunities: | Regular Research Grants |