Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds

Author(s)

Scarim, Caue Benito ; Chin, Chung Man

• Document type: Journal article
• Source: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY; v. 22, n. 12, p. 37-pg., 2022-01-01.

Abstract

Thiazoles, triazoles, and thiosemicarbazones function as efficient scaffolds in compounds for the treatment of several illnesses, including cancers. In this review article, we have demonstrated various studies involving these three pharmacophore classes (thiazoles, triazoles, and thiosemicarbazones) in medicinal chemistry over the last decade (2011-2021) with a focus on MCF-7 adenocarcinoma breast cancer cells. Our objective is to facilitate drug discovery of novel chemotherapeutic agents by detailing anti-proliferative compounds. (AU)

• FAPESP's process: 16/10847-9 - Hydroxymethylnitrofurazone (NFOH): activity study in chronic phase of Chagas' Disease in an animal model and synthesis of soluble derivatives
• Grantee: Cauê Benito Scarim
• Support Opportunities: Scholarships in Brazil - Doctorate