Sex under pressure: stress facilitates Leishmania in vitro hybridization

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Author(s):	Monte-Neto, Rubens L. ; Fernandez-Prada, Christopher ; Moretti, Nilmar S. Total Authors: 3
Document type:	Journal article
Source:	Trends in Parasitology; v. 38, n. 4, p. 3-pg., 2022-03-09.
Abstract
The selection of Leishmania hybrids in axenic culture was considered rare until recently, when Louradour and Ferreira et al., demonstrated that induced DNA damage facilitates genetic exchange, resulting in full genome tetraploid progenies in vitro. Meiosis-related gene homologues HAP2, GEX1, and RAD51 were found to be involved, opening new avenues for functional genomic studies. (AU)

FAPESP's process:	18/09948-0 - Study of protein acetylation in Leishmania
Grantee:	Nilmar Silvio Moretti
Support Opportunities:	Regular Research Grants