Beta-arrestins in the context of cardiovascular diseases: Focusing on angiotensin II type 1 receptor (AT1R)

Author(s)

Lino, Caroline Antunes ; Barreto-Chaves, Maria Luiza

• Document type: Journal article
• Source: CELLULAR SIGNALLING; v. 92, p. 9-pg., 2022-02-01.

Abstract

Cardiovascular diseases are the leading cause of death worldwide. The renin-angiotensin-aldosterone system is one of the major regulators of cardiovascular homeostasis and the angiotensin II type 1 receptor (AT1R) mediates the main deleterious effects resulting from the hyperactivation of this hormonal system. Beta-arrestins are multifunctional proteins that regulate the desensitization and internalization of G protein-coupled receptors. After the discovery of beta-arrestins, many efforts have been made towards characterizing and distinguishing this new signaling pathway for drug discovery. Here, we summarize recent advances that address the beta-arrestin signaling in the cardiovascular system, focusing on the activation of the AT1R. (AU)

• FAPESP's process: 13/16142-9 - THYROID HORMONE EFFECT IN ANGIOTENSIN II TYPE 1 RECEPTOR (AT1R) INTERNALIZATION AND ACTIVATION OF Ras/Raf/MEK/ERK IN CARDIOMYOCYTE HYPERTROPHY. BETA-ARRESTINS INVOLVEMENT.
• Grantee: Caroline Antunes Lino
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 16/13896-0 - AT1R internalization and Ras/Raf/MEK/ERK signaling in the cardiomyocyte hypertrophy induced by thyroid hormone. role of beta-arrestins
• Grantee: Maria Luiza de Morais Barreto de Chaves
• Support Opportunities: Regular Research Grants