Vaccines, adjuvants and key factors for mucosal immune response

Author(s)

Correa, Victor Araujo ; Portilho, Amanda Izeli ; De Gaspari, Elizabeth

• Document type: Journal article
• Source: IMMUNOLOGY; v. 167, n. 2, p. 15-pg., 2022-07-12.

Abstract

Vaccines are the most effective tool to control infectious diseases, which provoke significant morbidity and mortality rates. Most vaccines are administered through the parenteral route and can elicit a robust systemic humoral response, but they induce a weak T-cell-mediated immunity and are poor inducers of mucosal protection. Considering that most pathogens enter the body through mucosal surfaces, a vaccine that elicits protection in the first site of contact between the host and the pathogen is promising. However, despite the advantages of mucosal vaccines as good options to confer protection on the mucosal surface, only a few mucosal vaccines are currently approved. In this review, we discuss the impact of vaccine administration in different mucosal surfaces; how appropriate adjuvants enhance the induction of protective mucosal immunity and other factors that can influence the mucosal immune response to vaccines. (AU)

• FAPESP's process: 18/17945-1 - Comparative study of ELISA and ELISPOT techniques in the detection of antibodies IgG, IgM in isogenic strains of elderly mice
• Grantee: Thais Sousa Rodrigues
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 19/02042-9 - Evaluation of response profiles of Th1 and Th2 in mice immunized with anionic and cationic lipids complexed the outer membrane vesicles of Neisseria meningitis b
• Grantee: Victor Araujo Correa
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 12/15568-0 - Study of the immunogenicity of outer membrane antigens of Neisseria meningitidis and interaction with cationic lipids: evaluation of different immunization schedules in different strains of mice
• Grantee: Elizabeth Natal de Gaspari
• Support Opportunities: Regular Research Grants