| Full text | |
| Author(s): |
Saivish, Marielena Vogel
;
Menezes, Gabriela de Lima
;
da Costa, Vivaldo Gomes
;
Dutra da Silva, Gislaine Celestino
;
Marques, Rafael Elias
;
Nogueira, Mauricio Lacerda
;
Da Silva, Roosevelt Alves
Total Authors: 7
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 23, n. 14, p. 15-pg., 2022-07-01. |
| Abstract | |
The mosquito-borne disease caused by the Rocio virus is a neglected threat, and new immune inputs for serological testing are urgently required for diagnosis in low-resource settings and epidemiological surveillance. We used in silico approaches to identify a specific antigenic peptide (p_ROCV2) in the NS1 protein of the Rocio virus that was theoretically predicted to be stable and exposed on its surface, where it demonstrated key properties allowing it to interact with antibodies. These findings related to the molecular dynamics of this peptide provide important insights for advancing diagnostic platforms and investigating therapeutic alternatives. (AU) | |
| FAPESP's process: | 13/21719-3 - Epidemiological study of Dengue( serotypes1-4) Zika e chickungunya in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018 |
| Grantee: | Maurício Lacerda Nogueira |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 20/12875-5 - Development of the diagnostic method for Rocio virus and use of new compounds as inhibitors of flavivirus protease-helicase NS2B-NS3 |
| Grantee: | Marielena Vogel Saivish |
| Support Opportunities: | Scholarships in Brazil - Doctorate |