| Full text | |
| Author(s): |
Gunasekera, Brandon
;
Davies, Cathy
;
Blest-Hopley, Grace
;
Veronese, Mattia
;
Ramsey, Nick F.
;
Bossong, Matthijs G.
;
Radua, Joaquim
;
Bhattacharyya, Sagnik
;
CBE Consortium
Total Authors: 9
|
| Document type: | Journal article |
| Source: | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 140, p. 22-pg., 2022-08-02. |
| Abstract | |
The neurobiological mechanisms underlying the effects of delta-9-tetrahydrocannabinol (THC) remain unclear. Here, we examined the spatial acute effect of THC on human regional brain activation or blood flow (hereafter called 'activation signal') in a 'core' network of brain regions from 372 participants, tested using a within-subject repeated measures design under experimental conditions. We also investigated whether the neummodulatory effects of THC are related to the local expression of the cannabinoid-type-1 (CB1R) and type-2 (CB2R) receptors. Finally, we investigated the dose-response relationship between THC and key brain substrates. These metaanalytic findings shed new light on the localisation of the effects of THC in the human brain, suggesting that THC has neummodulatory effects in regions central to many cognitive tasks and processes, related to dose, with greater effects in regions with higher levels of CB1R expression. (AU) | |
| FAPESP's process: | 20/12110-9 - Cannabidiol (CBD) in patients with mild to moderate symptoms of coronavirus 2019: a randomized, double-blind, placebo-controlled clinical trial |
| Grantee: | José Alexandre de Souza Crippa |
| Support Opportunities: | Research Grants - Research in Public Policies |
| FAPESP's process: | 20/12066-0 - The emotional burden of SUS health teams involved in caring for patients with COVID-19: evaluation of the effectiveness of prophylactic measures, including the use of cannabidiol |
| Grantee: | Antonio Waldo Zuardi |
| Support Opportunities: | Research Grants - Research in Public Policies |