ERG11 Analysis among Clinical Isolates of Trichosporon asahii with Different Azole Susceptibility Profiles

Author(s)

de Almeida Jr, Joao Nobrega ; Jimenez-Ortigosa, Cristina ; Francisco, Elaine Cristina ; Colombo, Arnaldo L. L. ; Perlin, David S. S.

• Document type: Journal article
• Source: Antimicrobial Agents and Chemotherapy; v. 66, n. 12, p. 5-pg., 2022-11-14.

Abstract

We analyzed a cohort of Trichosporon asahii strains with different MICs of fluconazole and voriconazole and evaluated the presence of ERG11 mutations. ERG11 mutation conferring an amino acid change was found and its resistance potential was evaluated by cloning into Saccharomyces cerevisiae susceptible host strain. Transformants were not resistant to either fluconazole nor voriconazole. Our results suggest that ERG11 variants exist among T. asahii isolates, but are not responsible for resistance phenotypes. (AU)

• FAPESP's process: 18/19347-4 - Characterization of molecular mechanisms related to azoles resistance in Trichosporon asahii clinical isolates
• Grantee: João Nóbrega de Almeida Júnior
• Support Opportunities: Scholarships abroad - Research