| Full text | |
| Author(s): |
Abadjiev, Daniel S.
;
Toschi-Dias, Edgar
;
Salinet, Angela S. M.
;
Gaykova, Nicole N.
;
Lo, Men-Tzung
;
Nogueira, Ricardo C.
;
Hu, Kun
Total Authors: 7
|
| Document type: | Journal article |
| Source: | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM; v. N/A, p. 10-pg., 2023-02-01. |
| Abstract | |
Dynamic cerebral autoregulation (dCA) in healthy young adults displays a daily variation. Whether the rhythm exists in patients with stroke is unknown. We studied 28 stroke patients (age: 26-83 years, 7 females) within 48 hours after thrombolysis. dCA was assessed 54 times in these patients during supine rest (twice in 26 and once in 2 patients): 9 assessments between 0-9AM, 12 between 9AM-2PM, 20 between 2-7PM, and 13 between 7PM-12AM. To estimate dCA, phase shifts between spontaneous oscillations of cerebral blood flow velocity (CBFV) in the middle cerebral artery and arterial blood pressure (BP) were obtained in four frequency bands: <0.05 Hz, 0.05-0.1 Hz, 0.1-0.2 Hz, and >0.2 Hz. CBFV-BP phase shifts at <0.05 Hz were significantly larger between 2-7PM, suggesting better dCA, than those at other times (p < 0.0001), and the daily rhythm was consistent for stroke and non-stroke sides. No significant rhythms were observed at higher frequencies (all p > 0.2). All results were independent of age, sex, stroke type and severity, and other cardiovascular conditions. dCA after stroke showed a daily rhythm, leading to a better regulation of CBFV at <0.05 Hz during the afternoon. The finding may have implications for daily activity management of stroke patients. (AU) | |
| FAPESP's process: | 21/03076-4 - Prevention of stroke by means of non-invasive vagus nerve stimulation: a pilot randomised controlled trial |
| Grantee: | Edgar Toschi Dias |
| Support Opportunities: | Regular Research Grants |