An overview of sulfonamide-based conjugates: Recent advances for tuberculosis treatment

Author(s)

Scarim, Caue Benito ; Pavan, Fernando Rogerio

• Document type: Journal article
• Source: Drug Development Research; v. 83, n. 3, p. 11-pg., 2022-01-18.

Abstract

In 2019, tuberculosis (TB) caused approximately 1.4 million deaths around the world. TB is an infectious respiratory disease mainly caused by Mycobacterium tuberculosis. The lack of new drugs to treat drug-resistant strains is a principal factor for the continuous slow rise in TB infections. Sulfonamides are active moieties in various drugs used against several sicknesses, including TB. Our aim is to aid the development of new TB treatments and drugs by describing recent improvements (2011-2021) to sulfonamide-based compounds. (AU)

• FAPESP's process: 16/10847-9 - Hydroxymethylnitrofurazone (NFOH): activity study in chronic phase of Chagas' Disease in an animal model and synthesis of soluble derivatives
• Grantee: Cauê Benito Scarim
• Support Opportunities: Scholarships in Brazil - Doctorate