| Full text | |
| Author(s): |
Martins, Luis Ricardo Linard
;
Grzech-Lesniak, Kinga
;
Castro dos Santos, Nidia
;
Suarez, Lina J.
;
Giro, Gabriela
;
Bastos, Marta Ferreira
;
Shibli, Jamil Awad
Total Authors: 7
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH; v. 19, n. 12, p. 10-pg., 2022-06-01. |
| Abstract | |
Peri-implantitis is a plaque-associated condition characterized by mucosal inflammation and subsequent progressive loss of supporting bone; it is caused by bacterial biofilm, but the host response triggered by bacterial stimulation promotes the release of cells and mediators that culminate in tissue destruction. The Aryl-hydrocarbon Receptor (AhR) is associated with IL-22 production by Th22 and Th17 CD4+ Th cells. The presence of IL-6 may promote the Th22 phenotype. The present case-control study evaluated the gene expression of AhR, IL-22, and IL-6 in the peri-implant tissues of healthy and peri-implantitis patients. Tissue biopsies were collected from thirty-five volunteers (15 healthy and 20 with peri-implantitis). A real-time PCR reaction was utilized to assess the AhR, IL-22, and IL-6 gene expression levels relative to the reference gene (GAPDH). The results were analyzed using the Mann-Whitney test with a significance level of 5%. Higher levels of gene expression of AhR and IL-6 were detected in peri-implantitis tissues. The IL-22 gene expression levels did not differ between groups. In conclusion, higher gene expression levels for AhR and IL-6 were detected in the soft tissues of peri-implantitis patients. IL-22 did not vary between conditions, which may indicate the loss of the immunomodulatory role of IL-22 in periimplantitis. (AU) | |
| FAPESP's process: | 08/07154-5 - Immunological evaluation of surgical treatment of peri-implantitis using Er, Cr:YSGG associated with systemic antibiotics. |
| Grantee: | Luciana Aparecida de Gouveia Cardoso |
| Support Opportunities: | Scholarships in Brazil - Master |