A Systematic Review of Altered P300 Event-Related Potential in Apolipoprotein E4 (APOE4) Carriers

Author(s)

Pedroso, Renata Valle ; Fraga, Francisco Jose ; Pavarini, Sofia Cristina Iost ; Nascimento, Carla Manuela Crispim ; Ayan, Carlos ; Cominetti, Marcia Regina

• Document type: Journal article
• Source: CLINICAL EEG AND NEUROSCIENCE; v. 52, n. 3, p. 8-pg., 2020-09-18.

Abstract

Background Apolipoprotein epsilon 4 allele (APOE4) is the strongest genetic risk factor for Alzheimer's disease and seems to be related to cognitive decline and damaged event-related potential P300, which is a sensitive measure to assess cognitive processing. Objective This research aims to critically review the existing scientific evidence regarding the association betweenAPOE4and P300. Methods A systematic review was carried out up to January 2020 on the following databases: Web of Science, Scopus and Medline/PubMed. Articles were considered for inclusion if they are original research that provided information regarding the association betweenAPOE4and P300, available in English, Spanish, or Portuguese, and available in full text. The methodological quality of the studies selected was evaluated using the quality assessment tool for observational cohort and cross-sectional studies recommended by Cochrane. Results Out of 993 studies, 14 met the inclusion criteria. The results obtained showed thatAPOE4is related to a longer P300 latency. However, the data supplied do not allow us to confirm if this relationship also occurs in amplitude measures. Moreover, it was observed thatAPOEgenotype may influence P300 in different ages, from younger individuals to demented older people. Conclusion Evidence shows thatAPOE4negatively influences cortical activities related to cognitive functions, as indicated by P300. (AU)

• FAPESP's process: 17/18808-5 - Influence of APOE genotype and neurotrophic factors on event related potentials (ERP-P300) of elderly with Alzheimer's Disease and healthy elderly
• Grantee: Renata Valle Pedroso
• Support Opportunities: Scholarships in Brazil - Post-Doctoral