Mitochondrial connections with immune system in Zebrafish

Author(s)

do Amaral, Mariana Abrantes ; Paredes, Lais Cavalieri ; Padovani, Barbara Nunes ; Mendonca-Gomes, Juliana Moreira ; Montes, Luan Favero ; Saraiva Camara, Niels Olsen ; Fenero, Camila Morales

• Document type: Journal article
• Source: FISH AND SHELLFISH IMMUNOLOGY REPORTS; v. 2, p. 11-pg., 2021-12-01.

Abstract

Mitochondria are organelles commonly associated with adenosine triphosphate (ATP) formation through the oxidative phosphorylation (OXPHOS) process. However, mitochondria are also responsible for functions such as calcium homeostasis, apoptosis, autophagy, and production of reactive oxygen species (ROS) that, in conjunction, can lead to different cell fate decisions. Mitochondrial morphology changes rely on nutrients' availability and the bioenergetics demands of the cells, in a process known as mitochondrial dynamics, which includes both fusion and fission. This organelle senses the microenvironment and can modify the cells to either a pro or anti-inflammatory profile. The zebrafish has been increasingly used to research mitochondrial dynamics and its connection with the immune system since the pathways and molecules involved in these processes are conserved on this fish. Several genetic tools and technologies are currently available to analyze the behavior of mitochondria in zebrafish. However, even though zebrafish presents several similar processes known in mammals, the effect of the mitochondria in the immune system has not been so broadly studied in this model. In this review, we summarize the current knowledge in zebrafish studies regarding mitochondrial function and immuno metabolism. (AU)

• FAPESP's process: 17/05264-7 - Cell metabolism, microbiota and immune system: new paradigms in renal diseases physiopathology
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/21644-9 - Obesity-induced inflammation, alterations in the microbiota and their effects on the enteric nervous system: study in an experimental model of zebrafish.
• Grantee: Camila Idelí Morales Fénero
• Support Opportunities: Scholarships in Brazil - Doctorate