Nuclear factor erythroid 2-related factor 2 and autophagy regulation in cancer development

Author(s)

Dornas, Waleska

• Document type: Journal article
• Source: BIOPHYSICAL REVIEWS; v. 14, n. 5, p. 3-pg., 2022-10-01.

Abstract

Nuclear factor erythroid 2-related factor 2 (Nrf2) mitigates cell damage due to stress, environmental xenobiotics, and toxic chemicals. Nrf2 is present in the cytoplasm bound to its cysteine-rich Kelch domain-containing partner, Kelch-like ECH-associated protein 1 (Keap1), where is ubiquitinated and degraded. In addition to inducers that disrupt the Keap1-Nrf2 complex, defective autophagy has recently been shown to upregulate endogenous p62, which interacts with Keap1 triggering transcriptional activation of Nrf2 in several cancers. This regulation by Nrf2-dependent transactivation of cytoprotective genes needs to be validated by clinical trials in view of its persistent activation in a p62-dependent manner when there is deregulation of autophagy. (AU)

• FAPESP's process: 20/03697-6 - Study of the activities of the antioxidant proteins thioredoxin and thioredoxin reductase, associated with the development of human colon, breast and melanoma tumors
• Grantee: Waleska Claudia Dornas Amaral
• Support Opportunities: Scholarships in Brazil - Post-Doctoral