Extracellular vesicles in carcinoma microenvironment

Author(s)

de Carvalho-Silva, Larissa Tino ; Normando, Ana Gabriela C. ; Sa, Jamile de Oliveira ; dos Santos, Erison Santana ; De Rossi, Tatiane ; Busso-Lopes, Ariane Fidelis ; de Oliveira, Ana Karina ; Leme, Adriana F. Paes

• Document type: Journal article
• Source: BIOCHEMICAL SOCIETY TRANSACTIONS; v. N/A, p. 11-pg., 2023-04-06.

Abstract

Cancer is a significant cause of death, precluding increasing life expectancy worldwide. That is a multifactorial disease initiated by intrinsic or extrinsic factors that induce cell differentiation into cancer cells. However, cancer development, progression, and metastasis are not controlled only by cancer cells. The entire environment around these cells, named tumor microenvironment (TME), influences tumor development and spread. The tumor microenvironment is formed by cancer cells and heterogenous nonmalignant cells integrated with a complex extracellular matrix. The main cellular components of the TME are cancer-associated fibroblasts (CAFs), T lymphocytes, B cells, tumor-associated macrophages (TAMs), dendritic cells (DC), natural killer (NK) cells, tumor-associated neutrophils (TANs), Stem Cells, Endothelial Cells and their soluble secreted extracellular vesicles (EVs) that modulate cancer cells to establish and disseminate. This review provides a recent insight into the role of EVs secreted from different populations of the TME associated with the initiation and progression of carcinoma. (AU)

• FAPESP's process: 21/08034-8 - Study of the effect of extracellular vesicles from oral carcinoma models on neutrophil modulation
• Grantee: Larissa Tinô de Carvalho Silva
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 22/04490-1 - Validation of markers of malignant transformation into oral squamous cell carcinoma using imaging mass cytometry and targeted proteomics
• Grantee: Erison Santana dos Santos
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/03319-4 - Characterization of the role of tumor extracellular vesicles in tolerant tumor microenvironment through TCD4 lymphocyte modulation in oral carcinoma
• Grantee: Tatiane de Rossi Mazo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/09692-9 - Validation of target proteins associated with the progression of potentially malignant disorders into Oral Cancer
• Grantee: Ana Gabriela Costa Normando
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/05965-0 - Study of extracellular vesicles in the initiation of immune response by dendritic cells and T lymphocytes
• Grantee: Jamile de Oliveira Sá
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/18496-6 - The role of alcohol treated-extracellular vesicles in oral cells transformation
• Grantee: Adriana Franco Paes Leme
• Support Opportunities: Research Projects - Thematic Grants