Connexin-based Channels in the Liver

Author(s)

Van Campenhout, Raf ; Leroy, Kaat ; Cooreman, Axelle ; Tabernilla, Andres ; Cogliati, Bruno ; Kadam, Prashant ; Vinken, Mathieu

• Document type: Journal article
• Source: COMPREHENSIVE PHYSIOLOGY; v. 12, n. 4, p. 17-pg., 2022-10-01.

Abstract

Connexin proteins oligomerize in hexameric structures called connexin hemichannels, which then dock to form gap junctions. Gap junctions direct cell-cell communication by allowing the exchange of small molecules and ions between neighboring cells. In this way, hepatic gap junctions support liver homeostasis. Besides serving as building blocks for gap junctions, connexin hemichannels provide a pathway between the intracellular and the extracellular environment. The activation of connexin hemichannels is associated with acute and chronic liver pathologies. This article discusses the role of gap junctions and connexin hemichannels in the liver. (c) 2022 American Physiological Society. Compr Physiol 12:4147-4163, 2022. [GRAPHICS] . (AU)

• FAPESP's process: 18/10953-9 - Are connexins, pannexins and their (hemi)channels novel biomarkers and pharmacological targets in the prognosis and therapy of liver cancer?
• Grantee: Bruno Cogliati
• Support Opportunities: Regular Research Grants