| Full text | |
| Author(s): |
Pinto, Mariana Tomazini
;
Martins, Gisele Eiras
;
Vieira, Ana Glenda Santarosa
;
Galvao, Janaina Mello Soares
;
Souza, Cristiano de Padua
;
Macedo, Carla Renata Pacheco Donato
;
Lopes, Luiz Fernando
Total Authors: 7
|
| Document type: | Journal article |
| Source: | CANCERS; v. 15, n. 11, p. 23-pg., 2023-05-30. |
| Abstract | |
Simple Summary: Because ovarian germ cell tumors (OGCTs) are rare tumors, our current understanding of them is sparse; this is because few studies have investigated the molecular basis of pediatric and adult cancers. In this paper, we aim to provide an overview of the etiopathogenesis of OGCTs in children and adults, and we address the molecular landscape of these tumors.Ovarian germ cell tumors (OGCTs) are rare in adults; indeed, they occur predominantly in children, adolescents, and young adults, and they account for approximately 11% of cancer diagnoses in these groups. Because OGCTs are rare tumors, our current understanding of them is sparse; this is because few studies have investigated the molecular basis of pediatric and adult cancers. Here, we review the etiopathogenesis of OGCTs in children and adults, and we address the molecular landscape of these tumors, including integrated genomic analysis, microRNAs, DNA methylation, the molecular implications of treatment resistance, and the development of in vitro and in vivo models. An elucidation of potential molecular alterations may provide a novel field for understanding the pathogenesis, tumorigenesis, diagnostic markers, and genetic peculiarity of the rarity and complexity of OGCTs. (AU) | |
| FAPESP's process: | 19/07502-8 - Investigation of the transcription factors inducing Epithelial-Mesenchymal Transition (EMT) in germ cells tumors |
| Grantee: | Mariana Tomazini Pinto |
| Support Opportunities: | Research Grants - Young Investigators Grants |