Carotid intima-media thickness in adults with and without psoriasis - a nested case-control study from baseline data of ELSA-Brasil cohort

Author(s)

Tebar, William R. ; Santos, Itamar de S. ; Meneghini, Vandrize ; Bittencourt, Marcio Sommer ; Lotufo, Paulo A. ; Bensenor, Isabela M.

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING; v. 39, n. 8, p. 9-pg., 2023-06-08.

Abstract

There is a lack of consensus about the association between psoriasis (PSO) and carotid intima-media thickness (cIMT) in literature, since previous studies considered dermatologic clinic patients or general population. This study aimed to compare cIMT levels according to PSO in a sample of 10,530 civil servants form the ELSA-Brasil cohort study and analyze its association with the disease. The PSO cases and disease duration were identified by medical diagnosis self-reported at study enrollment. A paired group was identified by propensity score matching among all the participants without PSO. Mean cIMT values were considered for continuous analysis while cIMT above 75th percentile was considered for categorical analysis. Multivariate conditional regression models were used to analyze association between cIMT and PSO diagnosis, by comparing PSO cases against paired controls and overall sample without disease. A total of n = 162 PSO cases were identified (1.54%) and no difference in cIMT values was observed between participants with PSO and overall sample or control group. PSO was not associated with linear increment of cIMT (vs. overall sample: beta = 0.003, p = 0.690; vs. matched controls: beta = 0.004, p = 0.633) neither with increased chance of having cIMT above 75th percentile (vs. overall sample: OR = 1.06, p = 0.777; vs. matched controls: OR = 1.19, p = 0.432; conditional regression: OR = 1.31, p = 0.254). There was no relationship between disease duration and cIMT (beta = 0.000, p = 0.627). Although no significant relationship between mild cases of psoriasis and cIMT was observed among a wide cohort of civil servants, longitudinal investigation about cIMT progression and severity of disease are still needed. (AU)

• FAPESP's process: 19/23734-6 - Chronic inflammatory diseases and all-cause, cardiovascular and mortality related to other causes: association with risk factors, subclinical Atherosclerosis and fatal and non-fatal events in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
• Grantee: Isabela Judith Martins Bensenor
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 21/04416-3 - Association of Lupus, Sjogren, Vasculitis, Celiac Disease and Psoriasis with CAC at baseline and incidence/progression CAC, all-cause and CDV mortality in the 8-year follow-up of ELSA-Brasil
• Grantee: William Rodrigues Tebar
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/06798-0 - Autoimmune thyroid disease and inflammatory diseases: association with subclinical Atherosclerosis and general and cardiovascular mortality in ELSA-Brasil
• Grantee: Vandrize Meneghini
• Support Opportunities: Scholarships in Brazil - Post-Doctoral