DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes

Author(s)

Iglesias, Bernardo Almeida ; Peranzoni, Nickolas Pippi ; Faria, Sophia Iwersen ; Trentin, Luana Belo ; Schuch, Andre Passaglia ; Chaves, Otavio Augusto ; Bertoloni, Renan Ribeiro ; Nikolaou, Sofia ; de Oliveira, Kleber Thiago

• Document type: Journal article
• Source: Molecules; v. 28, n. 13, p. 16-pg., 2023-07-01.

Abstract

We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (TThPor, PdTThPor and PtTThPor). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscopy combined with molecular docking calculations. The results suggest that the interaction of these compounds probably occurs via secondary interactions via external grooves (minor grooves) around the DNA macromolecule. Moreover, porphyrins containing peripheral Pd(II) or Pt(II) complexes (PdTThPor and PtTThPor) were able to promote photo-damage in the DNA. (AU)

• FAPESP's process: 22/03478-8 - Reactivity of polynuclear ruthenium compounds with potential biological application
• Grantee: Sofia Nikolaou
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/06874-6 - Applications of technologies and synthetic methodologies developed under continuous flow conditions at LQBO-UFSCar for the preparation of molecules with biological activities and APIs
• Grantee: Kleber Thiago de Oliveira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC