Synthesis of Gluco-Alkynones via a Carbonylative Coupling Reaction Using 1-Iodoglucal

Author(s)

Paschoalin, Caio ; Toledo, Monica F. Z. J. ; Verissimo, Dayane ; Hornink, Milene M. ; Pimenta, Daniel C. ; Stefani, Helio A.

• Document type: Journal article
• Source: CHEMISTRYSELECT; v. 8, n. 35, p. 8-pg., 2023-09-20.

Abstract

Herein, we report a simple and efficient synthesis of gluco-alkynones obtained through the carbonylative coupling reaction of 1-iodoglucal, catalyzed by palladium. A broad range of gluco-alkynones were prepared with various aromatic aryl- and heteroaryl-substituted alkynes. The reaction proved to be limiting for alkyl and propargyl acetylenes. Reactions occur within short times and in moderate to excellent yields. A simple and efficient synthesis of gluco-alkynones obtained through the carbonylative coupling reaction of 1-iodoglucal, catalyzed by palladium. A broad range of gluco-alkynones were prepared with various aromatic aryl- and heteroaryl-substituted alkynes.image (AU)

• FAPESP's process: 20/00295-4 - Functionalization of D-glucal and analogs via carbonylative coupling reactions
• Grantee: Helio Alexandre Stefani
• Support Opportunities: Regular Research Grants