Recombinant antigen delivery to dendritic cells as a way to improve vaccine design

Author(s)

de Souza-Silva, Guilherme Antonio ; Sulczewski, Fernando Bandeira ; Boscardin, Silvia Beatriz

• Document type: Journal article
• Source: Experimental Biology and Medicine; v. N/A, p. 8-pg., 2023-09-25.

Abstract

Dendritic cells are central to the development of immunity, as they are specialized in initiating antigen-specific immune responses. In this review, we briefly present the existing knowledge on dendritic cell biology and how their division in different dendritic cell subsets may impact the development of immune responses. In addition, we explore the use of chimeric monoclonal antibodies that bind to dendritic cell surface receptors, with an emphasis on the C-type lectin family of endocytic receptors, to deliver antigens directly to these cells. Promising preclinical studies have shown that it is possible to modulate the development of immune responses to different pathogens when monoclonal antibodies fused to pathogen-derived antigens are used to deliver the antigen to different subsets of dendritic cells. This approach can be used to improve the efficacy of vaccines against different pathogens. (AU)

• FAPESP's process: 22/00204-4 - Influence of the STAT5 signaling pathway in conventional dendritic cells on the instruction of helper T cell response
• Grantee: Guilherme Antonio de Souza Silva
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 18/00145-2 - Influence of STAT1, STAT3, STAT5 and STAT6 signaling pathways on conventional dendritic cells in the instruction of auxiliary T cell response
• Grantee: Fernando Bandeira Sulczewski
• Support Opportunities: Scholarships in Brazil - Doctorate