Cobalt(III)-py₂en systems as potential carriers of β-ketoester-based ligands

Author(s)

Palmeira-Mello, Marcos, V ; Caballero, Ana B. ; Herrera-Ramirez, Piedad ; Costa, Analu R. ; Santana, Savyo S. ; Guedes, Guilherme P. ; Caubet, Amparo ; Batista, Alzir Azevedo ; Gamez, Patrick ; Lanznaster, Mauricio

• Document type: Journal article
• Source: Journal of Inorganic Biochemistry; v. 248, p. 11-pg., 2023-11-01.

Abstract

Two cobalt(III) complexes containing different beta-ketoesters, namely [Co-III(L1)(py(2)en)](ClO4)(2)center dot H2O (1) and [Co-III(L2)(py(2)en)](ClO4)(2) (2) (py(2)en = N,N '-bis(pyridin-2-ylmethyl)ethylenediamine; L1(-) = methylacetoacetate; L2(-) = ethyl 4-chloroacetoacetate) have been prepared and investigated as prototypes of bioreductive prodrugs. The presence of beta-ketoester and py(2)en ligands in 1 and 2, as well as the perchlorate counterions, was supported by IR spectroscopy and CHN elemental analysis. The composition molecular structure of both complexes was confirmed by NMR spectroscopy and ESI mass spectrometry. Structural information was also obtained for 2 via X-ray diffraction analysis. The redox properties indicate that 1 and 2 are suitable for reduction under biological conditions. Investigation of DNA-interacting suggest that 1 and 2 bind DNA via electrostatic forces. Both complexes may be employed as possible platforms for the delivery of biologically active compounds, since their reaction with ascorbic acid in PBS at pH 6.2 and 7.4 at 37 degrees C results in the release of the beta-ketoester ligands upon Co(III)/Co(II) reduction. (AU)

• FAPESP's process: 21/01787-0 - In vitro and in vivo study of Ru(II)/phosphine complexes with anticancer activities
• Grantee: Marcos Vinícius Palmeira de Mello
• Support Opportunities: Scholarships in Brazil - Post-Doctoral