Deferoxamine Interference in Fibro-inflammation: Additional Action in Control of Obese Adipose Tissue Dysfunction

Author(s)

Gotardo, Erica Martins Ferreira ; de Morais, Thaina Rodrigues ; Ferreira, Ana Paula Timoteo ; Caria, Cintia Rabelo e Paiva ; Ribeiro, Marcelo Lima ; Gambero, Alessandra

• Document type: Journal article
• Source: CURRENT DRUG TARGETS; v. 24, n. 8, p. 9-pg., 2023-01-01.

Abstract

Introduction Several studies demonstrated that deferoxamine, an iron chelator, can improve inflammatory alterations in adipose tissue induced by obesity. Obesity alterations in adipose tissue are also associated with tissue remodeling, and deferoxamine has anti-fibrosis action previously described in sites like the skin and liver. Methods In this work, we analyzed deferoxamine effects on adipose tissue fibro-inflammation during obesity induced by diet in mice. in vitro approaches with fibroblasts and macrophages were also carried out to elucidate deferoxamine activity. Results Our results demonstrated that in addition to exerting anti-inflammatory effects, reducing the cytokine production in adipose tissue of obese mice and by human monocyte differentiated in macrophage in vitro, deferoxamine can alter metalloproteinases expression and extracellular matrix production in vivo and in vitro. Conclusion Deferoxamine could be an alternative to control fibro-inflammation in obese adipose tissue, contributing to the metabolic improvements previously described. (AU)

• FAPESP's process: 14/04986-0 - Evaluation of macrophage phenotype upon hepcidin expression and iron influx: a possible local role in adipose tissue.
• Grantee: Ana Paula Timóteo Ferreira
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 18/03665-7 - Iron chelators activity on adipose tissue and skeletal muscle in obese mice and in vitro in 3T3-L1 and C2C12 cells
• Grantee: Thainá Rodrigues de Morais
• Support Opportunities: Scholarships in Brazil - Master