Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Author(s)

Gomes, Caio Perez ; Torloni, Maria Regina ; Gueuvoghlanian-Silva, Barbara Yasmin ; Alexandre, Sandra Maria ; Mattar, Rosiane ; Daher, Silvia

• Document type: Journal article
• Source: American Journal of Reproductive Immunology; v. 69, n. 6, p. 13-pg., 2013-06-01.

Abstract

Problem Gestational diabetes mellitus (GDM) is an inflammatory condition that involves unbalanced cytokine production. We carried out a systematic review on the relationship between GDM and maternal circulating levels of cytokines in the 2nd/3rd trimesters. Method of Study Three electronic databases (MEDLINE, EMBASE and LILACS), were searched. Duplicate study selection, extraction and quality assessment was performed. Results Twenty-two studies with 1982 participants reporting levels of 9 cytokines (IL-1B, IL-2, IL-6, IL-10, IL-13, IL-18, IFN-G, TGF-B and TNF-A) were included. Most studies differed considerably in selection criteria, sampling and assay methods and in reporting their results. Consequently, only two studies could be pooled: TNF-A concentration was slightly higher in GDM than in control patients, although not significant (WMD=0.45, 95% CI 0.341.23). Conclusions New studies with well-defined, more homogeneous methodological parameters are needed to detect whether there are significant differences in circulating levels of cytokines in patients with GDM. (AU)

• FAPESP's process: 10/52547-5 - Inflammatory mediators in overweight pregnant women
• Grantee: Silvia Daher
• Support Opportunities: Regular Research Grants