Gold Nanoparticles Improve Clinical Parameters and Reduce Neurological Alterations in Sepsis-Induced Mice

Author(s)

Ferreira, Joao P. ; Di Bella, Davide ; Andreotti, Diana Z. ; Cortes, Bryan F. ; Carvalho, Maria H. ; Kawamoto, Elisa M. ; Rodrigues, Stephen F.

• Document type: Journal article
• Source: JOURNAL OF BIOMEDICAL NANOTECHNOLOGY; v. 19, n. 1, p. 12-pg., 2023-01-01.

Abstract

Sepsis is a grave systemic condition that affects several organs and is caused by an infectious disease. Among the organs targeted by sepsis is the brain, a condition named sepsis-associated encephalopathy (SAE). Epidemiological studies indicate that 25%-70% of sepsis patients develop SAE, presenting acute and chronic symptoms. The main acute symptom is delirium, while chronic symptoms include cognitive impairment, locomotor dysfunction and mood disorders, amongst them, depression. The physiopathology of SAE involves systemic and local actions. Systemically, reduced brain perfusion, hyperglycemia, and activation of the sensory vagus nerve contribute to SAE. Locally, inflammation, enhanced IP: 2038 10920 On: Wed 03 May 2023 10 24:4 oxidative stress, and enhanced excitotoxicitplay vital roles in SAE development. Today, there is no commercially avail-Copyrght: American Scientific Publishe s able treatment for SAE. We recently demonstratedthatDelivered btwenty-nanometerIngentacitrate-capped gold nanoparticles (cit-AuNP) intravenously injected two or four hours after induction of sepsis could reduce cerebral inflammation in mice. In the present study, we showed that cit-AuNP acutely injected in mice with sepsis exhibited faster clinical symptom resolution and reduced glutamate levels in the brain thirty days after sepsis induction. The acute twenty-nanometer cit-AuNP treatment also prevented depression-like behavior in mice after a sepsis episode. Thus, cit-AuNP therapy may potentially be used to prevent sepsis-induced depression. (AU)

• FAPESP's process: 14/05146-6 - Therapeutical efficacy of gold nanoparticles to glioblastoma multiform or septic encephalopathy in mice
• Grantee: Stephen Fernandes de Paula Rodrigues
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 20/16756-0 - Effect of sepsis severity on the leukocyte adhesion in pial blood vessels, locomotor activity and depressive-like behavior in mice
• Grantee: Bryan Fellipe da Silva Cortes
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 20/07212-7 - Effect of doxycycline, secretory leukocyte protease inhibitor (SLPI), inhaled aldosterone or gold nanoparticles treatment in a murine model of acute respiratory distress syndrome
• Grantee: Stephen Fernandes de Paula Rodrigues
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/18602-5 - Therapeutic efficacy of gold nanoparticles in septic encephalopathy in mice
• Grantee: Davide Di Bella
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 18/12258-6 - Effect of gold nanoparticles treatment on the acute expression of inflammatory transcription factors and on the chronic expression of excitatory neurotransmiters in brain of sepsis encephalophaty-induced mice
• Grantee: João Paulo de Sousa Ferreira
• Support Opportunities: Scholarships in Brazil - Scientific Initiation