Visible-Light Mediated Carbamoylation of Nitrones under a Continuous Flow Regime

Author(s)

Oliveira, Pedro H. R. ; Tordato, Everton A. ; Velez, Jeimy A. C. ; Carneiro, Pablo S. ; Paixao, Marcio W.

• Document type: Journal article
• Source: Journal of Organic Chemistry; v. 88, n. 10, p. 13-pg., 2023-05-19.

Abstract

Herein, we report a rapid and scalable continuous-flowphotocatalyticapproach for the carbamoylation of nitrones. This protocol makes useof readily available 4-amido-1,4 dihydropyridines as carbamoyl radicalprecursors. The scope of this transformation exhibits high compatibilitywith complex structures containing amino acids, peptides, and glycosides.Importantly, the developed method allows a photocatalytic syntheticstrategy in combination with flow conditions, maximizing the potentialand efficiency for the synthesis of valuable alpha-(N-hydroxy)-amino amides. (AU)

• FAPESP's process: 21/06099-5 - Development of new photochemical methodologies for the synthesis of small molecule and biomolecule modifications
• Grantee: Márcio Weber Paixão
• Support Opportunities: Regular Research Grants