Extracellular vesicles throughout development: A potential roadmap for emerging glioblastoma therapies

Author(s)

Fernandes, Camila Felix de Lima ; Coelho, Barbara Paranhos ; Souza, Maria Clara da Silva ; Boccacino, Jacqueline Marcia ; Soares, Samuel Ribeiro ; de Araujo, Jao Pedro Alves ; Melo-Escobar, Maria Isabel ; Lopes, Marilene Hohmuth

• Document type: Journal article
• Source: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY; v. 133, p. 10-pg., 2023-01-15.

Abstract

Extracellular vesicles (EVs) are membrane-delimited vesicular bodies carrying different molecules, classified according to their size, density, cargo, and origin. Research on this topic has been actively growing through the years, as EVs are associated with critical pathological processes such as neurodegenerative diseases and cancer. Despite that, studies exploring the physiological functions of EVs are sparse, with particular emphasis on their role in organismal development, initial cell differentiation, and morphogenesis. In this review, we explore the topic of EVs from a developmental perspective, discussing their role in the earliest cell-fate decisions and neural tissue morphogenesis. We focus on the function of EVs through development to highlight possible conserved or novel processes that can impact disease progression. Specifically, we take advantage of what was learned about their role in development so far to discuss EVs impact on glioblastoma, a particular brain tumor of stem-cell origin and poor prognosis, and how their function can be hijacked to improve current therapies. (AU)

• FAPESP's process: 21/13070-3 - Differential PrPC expression and correlated genes in patient-derived Glioblastoma stem cells and its consequence to the tumor maintenance and lineage commitment
• Grantee: Maria Clara da Silva Souza
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 19/14952-0 - Characterization of intracellular signaling pathways modulated by the cellular prion protein on stemness maintenance in glioblastoma stem cells
• Grantee: Bárbara Paranhos Coelho
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/11097-1 - Modulation of the neural phenotype of glioblastoma stem cells by extracellular miRNA from NSCs
• Grantee: Maria Isabel Melo Escobar
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 19/14741-9 - Study of the role of STI1 and assotiated factors in the proteostasis network and pluripotency regulation
• Grantee: Camila Felix de Lima Fernandes
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 20/05443-1 - Effects of STI1 variation on phenotypic manifestation of different pluripotent status
• Grantee: Samuel Ribeiro Soares
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 18/15557-4 - Prion protein and its partners: emerging targets for glioblastoma stem cell based-therapy
• Grantee: Marilene Hohmuth Lopes
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 21/05287-2 - Comparative analysis of STI1 differential expression on transcriptomic profile of pluripotent stem cell
• Grantee: João Pedro Alves de Araújo
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 20/07450-5 - Evaluation of transcript levels of PrPc downstream targets and intracellular signaling pathways in glioblastoma stem cells
• Grantee: Jacqueline Marcia Boccacino
• Support Opportunities: Scholarships in Brazil - Scientific Initiation