Involvement of brain cell phenotypes in stress-vulnerability and resilience

Author(s)

Favoretto, Cristiane Aparecida ; Pagliusi, Marco ; Morais-Silva, Gessynger

• Document type: Journal article
• Source: FRONTIERS IN NEUROSCIENCE; v. 17, p. 14-pg., 2023-07-05.

Abstract

Stress-related disorders' prevalence is epidemically increasing in modern society, leading to a severe impact on individuals' well-being and a great economic burden on public resources. Based on this, it is critical to understand the mechanisms by which stress induces these disorders. The study of stress made great progress in the past decades, from deeper into the hypothalamic-pituitary-adrenal axis to the understanding of the involvement of a single cell subtype on stress outcomes. In fact, many studies have used state-of-the-art tools such as chemogenetic, optogenetic, genetic manipulation, electrophysiology, pharmacology, and immunohistochemistry to investigate the role of specific cell subtypes in the stress response. In this review, we aim to gather studies addressing the involvement of specific brain cell subtypes in stress-related responses, exploring possible mechanisms associated with stress vulnerability versus resilience in preclinical models. We particularly focus on the involvement of the astrocytes, microglia, medium spiny neurons, parvalbumin neurons, pyramidal neurons, serotonergic neurons, and interneurons of different brain areas in stress-induced outcomes, resilience, and vulnerability to stress. We believe that this review can shed light on how diverse molecular mechanisms, involving specific receptors, neurotrophic factors, epigenetic enzymes, and miRNAs, among others, within these brain cell subtypes, are associated with the expression of a stress-susceptible or resilient phenotype, advancing the understanding/knowledge on the specific machinery implicate in those events. (AU)

• FAPESP's process: 21/13291-0 - Evaluating the consequences of psychosocial stress exposure to the functional lateralization of the media prefrontal cortex: a morphological and functional approach
• Grantee: Gessynger Morais Silva
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 20/08363-9 - Study of the modulation of afferent pathways to the rostral ventromedial medulla in depressive-like behavior and hyperalgesia induced by social stress in mice
• Grantee: Marco Oreste Finocchio Pagliusi Junior
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 22/10168-5 - Impacts of chronic intermittent ethanol vapor and stress exposure on striatal D1 medium spiny neurons: modulation by CB1 cannabinoid receptors
• Grantee: Cristiane Aparecida Favoretto
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 19/24073-3 - Role of cannabinoid CB1 receptors in modulating neural circuits involved in the interaction between maternal separation stress and ethanol intake in mice
• Grantee: Cristiane Aparecida Favoretto
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 20/15216-2 - Evaluation of the medial prefrontal cortex interhemispheric connections in the resilience and susceptibility to the social defeat stress: because the side matters
• Grantee: Gessynger Morais Silva
• Support Opportunities: Scholarships in Brazil - Post-Doctoral